RAF Typhoon FGR4s have operated alongside French warplanes in a combined operation targeting an subterranean weapons facility in Syria operated by the IS group, per a report from the UK's MoD.
The site, identified by reconnaissance, was assessed as storing arms and explosives, the announcement noted, and was located in mountains just north of the historic site of Palmyra in Syria's central region.
"Our aircraft employed precision-guided Paveway IV munitions to hit a several entry passages down to the depot... preliminary assessments suggest the objective was successfully hit," the MoD said.
There was no indication of any harm to civilians in the strike on Saturday evening and all the aircraft returned to base without incident, the MoD added.
The British jets were supported by a Voyager refuelling tanker.
The Islamic State group - alternatively referred to as the so-called Islamic State - enforced extremist governance over large swathes of Iraq and Syria prior to its 2019 collapse.
"This action demonstrates British leadership, and commitment to stand shoulder to shoulder with our allies, to eliminate any revival of Daesh and their dangerous and violent ideologies in the area," the British Defence Secretary the Defence Secretary stated.
British military aircraft have performed patrols over Syrian airspace to "forestall any attempted resurgence" of IS after its defeat at the Baghuz confrontation in 2019, the ministry said.
"I must thank the personnel of British forces who took part in this strike for their expertise and their bravery," he added. "Including them were numerous UK service members on duty over Christmas and New Year. This action, to eliminate dangerous terrorists who pose a risk to our security, highlights how British military are prepared to act, throughout the year, protecting the UK at home and influential overseas."
Last December, the United States armed forces executed what it termed a "large-scale strike" targeting Islamic State objectives in the country, subsequent to an assault resulted in the deaths of two US troops and a local interpreter in Palmyra.
The U.N. says IS still has between 5,000 and 7,000 fighters in Syria and Iraq.